<scp>EGFR</scp>‐<scp>KDD</scp> Myofibroblastic Neoplasm or Congenital Peribronchial Myofibroblastic Tumor (<scp>CPMT</scp>)? Report of a Congenital Myofibroblastic Neoplasm With Unusual Histologic Features
EGFR-kinase-domain duplication (KDD) has been reported in Infantile fibrosarcoma-like myofibroblastic tumors and cellular mesoblastic nephroma. We report a pulmonary neoplasm with EGFR-(KDD) and infantile fibrosarcoma-like histologic features in a female infant with an unusual clinical and histologic evolution, characterized by persistent disease with morphologic features of Congenital Peribronchial Myofibroblastic Tumor (CPMT) after chemotherapy and targeted therapy. The CPMT morphology with EGFR-KDD in the post-therapy specimen might be an evolution induced by the treatment, which suggests the hypothesis that CPMT is part of the morphologic spectrum of infantile fibrosarcoma/cellular mesoblastic nephroma.
Authors
- Michela Casanova (ORCID: https://orcid.org/0000-0003-0368-7883)
- Sabrina Rossi (ORCID: https://orcid.org/0000-0001-9122-1308)
- Rita Alaggio (ORCID: https://orcid.org/0000-0003-3915-3816)
- Glória Pelizzo (ORCID: https://orcid.org/0000-0002-5253-8828)
- Evelina Miele (ORCID: https://orcid.org/0000-0002-4747-1032)
- Stefano Chiaravalli (ORCID: https://orcid.org/0000-0002-3044-6578)
- Sabina Barresi (ORCID: https://orcid.org/0000-0002-7307-388X)
- Marta Barisella (ORCID: https://orcid.org/0000-0001-9728-3120)
- Emma Rullo (ORCID: https://orcid.org/0000-0003-4152-5025)
- Sara Patrizi (ORCID: https://orcid.org/0000-0003-1898-1516)
- Andrea C. Ferrari (ORCID: https://orcid.org/0000-0002-4724-0517)
Institutions
- University of Milan (IT)
- Luigi Sacco Hospital (IT)
- Bambino Gesù Children's Hospital (IT)
- Ospedale dei Bambini Vittore Buzzi (IT)
- Fondazione IRCCS Istituto Nazionale dei Tumori (IT)
- ASST Fatebenefratelli Sacco (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Genes Chromosomes and Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/gcc.70032
- Citations
- 2
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01