Agonism at mGluR2 receptors reduces dysfunctional checking on a rodent analogue of compulsive-like checking in obsessive compulsive disorder

The similarity in effect of AZD-8529 and LY404039 suggests that the capacity of these drugs to reduce checking is mediated by mGluR2s, which may provide a promising target for future treatment development for OCD.

Authors

Colin McKenzie (ORCID: https://orcid.org/0000-0001-9867-6735)
Amy Milton (ORCID: https://orcid.org/0000-0003-0175-9417)
Felippe E. Amorim (ORCID: https://orcid.org/0000-0002-1922-8211)
Trevor William Robbins (ORCID: https://orcid.org/0000-0003-0642-5977)
Bart Sloot

Institutions

Radboud University Nijmegen (NL)
University of Cambridge (GB)

Publication Details

Journal: Psychopharmacology
Published: 2025-04-03
DOI: https://doi.org/10.1007/s00213-025-06774-2
Citations: 1
Primary Topic: Obsessive-Compulsive Spectrum Disorders
Type: article
Field-Weighted Citation Impact: 2.31

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article

Agonism at mGluR2 receptors reduces dysfunctional checking on a rodent analogue of compulsive-like checking in obsessive compulsive disorder

Colin McKenzie, Amy Milton, Felippe E. Amorim, Trevor William Robbins et al.

Apr 3, 2025

1 citations

Psychopharmacology

Obsessive-Compulsive Spectrum Disorders

2.31

article

Agonism at mGluR2 receptors reduces dysfunctional checking on a rodent analogue of compulsive-like checking in obsessive compulsive disorder

Colin McKenzie, Amy Milton, Felippe E. Amorim, Trevor William Robbins, Bart Sloot

April 3, 2025article en

1 citations

Abstract

The similarity in effect of AZD-8529 and LY404039 suggests that the capacity of these drugs to reduce checking is mediated by mGluR2s, which may provide a promising target for future treatment development for OCD.

PsychopharmacologyVol. 242(8)

Radboud University Nijmegen (NL), University of Cambridge (GB)

Good health and well-being

Openalex Percentile: Top 16%

Obsessive-Compulsive Spectrum Disorders

2.31

DOI Open Access PDF OpenAlex

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