Neuroprotective effect of riboflavin kinase on cerebral ischemia injury in rats
The present study demonstrates that RFK is an important regulatory molecule against ischemia brain injury and its mechanism involves inhibition of ERS. The protective effect of RFK is independent of the presence of flavins and their concentrations. RFK deserves further investigation as a promising target gene for the detection of stroke susceptibility. Flavins may be used as a preventive or adjunctive treatments for ischemic brain injury.
Authors
- Weihong Liu (ORCID: https://orcid.org/0000-0002-1241-517X)
- Ming-Hua Ruan
- Yingxin Zou (ORCID: https://orcid.org/0000-0003-0570-5432)
- Song Chen (ORCID: https://orcid.org/0000-0003-2896-8235)
- Feng Xu (ORCID: https://orcid.org/0000-0002-8268-0155)
- Zhi-Yong Chu (ORCID: https://orcid.org/0000-0003-4235-3704)
- Liu Fei (ORCID: https://orcid.org/0000-0001-7603-9436)
Institutions
- Naval Medical Research Command (US)
- Naval Aerospace Medical Research Laboratory (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s10020-025-01170-0
- Citations
- 1
- Primary Topic
- RNA regulation and disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China