Minimal Physiologically-Based Pharmacokinetic Modeling of Atenolol and Metoprolol Absorption in Malnourished Rats
This study demonstrated advantageous use of mPBPK modeling with malnutrition primarily altering drug absorption in this animal model. Also, our analysis offers a blend of known and assumed components assembled mechanistically to suggest a reasonable interpretation of the PK profiles.
Authors
- Selma Şahin
- William J. Jusko (ORCID: https://orcid.org/0000-0003-4027-0550)
- Fatma Kir (ORCID: https://orcid.org/0000-0001-8952-641X)
Institutions
- University at Buffalo, State University of New York (US)
- Hacettepe University (TR)
Publication Details
- Journal
- European Journal of Drug Metabolism and Pharmacokinetics
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1007/s13318-025-00943-6
- Citations
- 4
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 6.23
Funders
- Türkiye Bilimsel ve Teknolojik Araştırma Kurumu
- Hacettepe Üniversitesi
- National Institute of General Medical Sciences