Parent-of-origin effects in the life-course evolution of cardiometabolic traits

Our study provides proof of concept of the existence of parent-of-origin effects on cardiometabolic traits from birth, through childhood and puberty, until adult age. Our results indicate a predominantly maternal influence on intrauterine, pubertal and reproductive-age metabolism in the offspring. While the longitudinal analysis indicated a maternal bias for the macronutrients (glucose and lipids), and a paternal bias for glucose-insulin metabolism, the cross-sectional analysis revealed a transition between parental influence across physiological stages. This dynamic relationship may have its origins in the life-history theory of evolution, and could inform strategies for primordial prevention aimed at curbing the rising burden of cardiometabolic disease. Further studies are needed to determine the mechanisms underlying such effects.

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Publication Details

Journal
Diabetologia
Published
2025-04-02
DOI
https://doi.org/10.1007/s00125-025-06396-5
Citations
1
Primary Topic
Birth, Development, and Health
Type
article
Field-Weighted Citation Impact
3.49

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article

Parent-of-origin effects in the life-course evolution of cardiometabolic traits

Jonas Andersson, Rashmi B. Prasad, Chittaranjan S. Yajnik, Pooja Kunte et al.
1 citations
Diabetologia
Birth, Development, and Health
3.49
article

Parent-of-origin effects in the life-course evolution of cardiometabolic traits

Jonas Andersson, Rashmi B. Prasad, Chittaranjan S. Yajnik, Pooja Kunte, Rucha Wagh, Gad Hatem, Souvik Bandyopadhyay
article en
1 citations

Abstract

Our study provides proof of concept of the existence of parent-of-origin effects on cardiometabolic traits from birth, through childhood and puberty, until adult age. Our results indicate a predominantly maternal influence on intrauterine, pubertal and reproductive-age metabolism in the offspring. While the longitudinal analysis indicated a maternal bias for the macronutrients (glucose and lipids), and a paternal bias for glucose-insulin metabolism, the cross-sectional analysis revealed a transition between parental influence across physiological stages. This dynamic relationship may have its origins in the life-history theory of evolution, and could inform strategies for primordial prevention aimed at curbing the rising burden of cardiometabolic disease. Further studies are needed to determine the mechanisms underlying such effects.

DiabetologiaVol. 68(6)
Lund University (SE), Symbiosis International University (IN), Institute for Molecular Medicine Finland (FI), King Edward Memorial Hospital Research Centre (IN), Cytel (United States) (US)
Åke Wiberg Stiftelse, Wellcome Trust, Department of Biotechnology, Ministry of Science and Technology, India, Indian Council of Medical Research, VINNOVA, Crafoordska Stiftelsen, Lunds Universitet, Vetenskapsrådet, European Association for the Study of Diabetes, Medical Research Council
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Birth, Development, and Health
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Parent-of-origin effects in the life-course evolution of cardiometabolic traits — Jonas Andersson, Rashmi B. Prasad, et al. · Diabetologia (2025) | TGRS Research Map | TGRS