Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (<scp>SED</scp>‐<scp>CARE</scp>): A protocol for a randomized clinical trial
The SED-CARE trial will investigate if continuous deep sedation (RASS -4/-5) for 36 h confers a mortality benefit compared to minimal sedation (RASS 0 to -2) after cardiac arrest.
Authors
- Ameldina Ceric (ORCID: https://orcid.org/0000-0001-6846-5961)
- Timo Kaakinen (ORCID: https://orcid.org/0000-0001-5125-245X)
- Johanna Hästbacka (ORCID: https://orcid.org/0000-0002-3613-7231)
- Josef Dankiewicz (ORCID: https://orcid.org/0000-0002-6312-6749)
- Tobias Cronberg (ORCID: https://orcid.org/0000-0002-3442-3058)
- Judith White (ORCID: https://orcid.org/0000-0002-4557-3393)
- David Pogson
- Andreas Lundin (ORCID: https://orcid.org/0000-0002-6623-6847)
- M. V. Ramanan
- Matthias Hænggi (ORCID: https://orcid.org/0000-0001-5845-031X)
- Stepani Bendel
- Jessica Kåhlin (ORCID: https://orcid.org/0000-0001-5266-5272)
- Guy Glover (ORCID: https://orcid.org/0000-0003-1357-1817)
- Caroline Barkholt Kamp (ORCID: https://orcid.org/0000-0002-7756-4694)
- David Knight (ORCID: https://orcid.org/0000-0003-2156-4297)
- Yaseen M. Arabi (ORCID: https://orcid.org/0000-0001-5735-6241)
- Chia Yew Woon
- Janus Christian Jakobsen (ORCID: https://orcid.org/0000-0002-3642-2120)
- Jens Nee
- Jesper Johnsson (ORCID: https://orcid.org/0000-0003-0651-3811)
- Hans Friberg (ORCID: https://orcid.org/0000-0002-5588-0098)
- Michael Joannidis (ORCID: https://orcid.org/0000-0002-6996-0881)
- Marjaana Tiainen (ORCID: https://orcid.org/0000-0001-5107-1990)
- Koen Ameloot (ORCID: https://orcid.org/0000-0001-7071-8825)
- Candice Delcourt (ORCID: https://orcid.org/0000-0003-2257-4286)
- Paul Jeffrey Young (ORCID: https://orcid.org/0000-0002-3428-3083)
- Anthony Delaney (ORCID: https://orcid.org/0000-0002-1015-7146)
- Daniel Rob (ORCID: https://orcid.org/0000-0002-3927-2674)
- Kevin Sweet
- Marion Moseby‐Knappe (ORCID: https://orcid.org/0000-0001-8160-5957)
- Luis Romundstad (ORCID: https://orcid.org/0000-0003-0552-1668)
- Gisela Lilja (ORCID: https://orcid.org/0000-0003-1860-1456)
- Patrick Druwé
- Matteo Nafi (ORCID: https://orcid.org/0000-0003-2733-9103)
- Jan Holgersson (ORCID: https://orcid.org/0000-0003-2202-6511)
- Frances Bass (ORCID: https://orcid.org/0000-0003-3826-8558)
- Joachim Düring (ORCID: https://orcid.org/0000-0003-1538-9824)
- Matti Reinikainen (ORCID: https://orcid.org/0000-0001-6878-3740)
- Jan Bělohlávek (ORCID: https://orcid.org/0000-0001-9455-9224)
- Christoph Leithner (ORCID: https://orcid.org/0000-0002-8277-846X)
- Claudia Schrag
- Thomas R. Keeble (ORCID: https://orcid.org/0000-0001-8695-7994)
- Annerose Mengel (ORCID: https://orcid.org/0000-0002-2399-3020)
- Matthias P. Hilty (ORCID: https://orcid.org/0000-0002-2765-881X)
- Philip Hopkins (ORCID: https://orcid.org/0000-0002-3713-8391)
- Michael C. Reade (ORCID: https://orcid.org/0000-0003-1570-0707)
- Tobias Graf (ORCID: https://orcid.org/0000-0003-4038-147X)
- L Navarra
- Tommaso Pellis (ORCID: https://orcid.org/0000-0002-3113-6811)
- Manoj Saxena (ORCID: https://orcid.org/0000-0002-0385-6731)
- Hilton Levin
- Matt P. Wise (ORCID: https://orcid.org/0000-0002-2763-4316)
- Eno-Martin Lotman (ORCID: https://orcid.org/0000-0002-7054-9571)
- Joonas Tirkkonen (ORCID: https://orcid.org/0000-0001-7081-4227)
- Philippa Jackson (ORCID: https://orcid.org/0000-0001-8836-6450)
- Niklas Nielsen (ORCID: https://orcid.org/0000-0002-6013-126X)
- Naomi E. Hammond (ORCID: https://orcid.org/0000-0002-6559-7747)
- Markus B. Skrifvars (ORCID: https://orcid.org/0000-0002-0341-0262)
- Manuela Iten (ORCID: https://orcid.org/0000-0002-0140-2066)
- Anders Åneman (ORCID: https://orcid.org/0000-0003-2096-5304)
- Nikos Gorgoraptis (ORCID: https://orcid.org/0000-0002-2588-9235)
- Anna Lybeck (ORCID: https://orcid.org/0000-0001-7574-3958)
- Christopher Remmington (ORCID: https://orcid.org/0000-0001-5600-8368)
- Johan Undén (ORCID: https://orcid.org/0000-0002-8344-5720)
- Chiara Robba (ORCID: https://orcid.org/0000-0003-1628-3845)
- Jonathan Grip (ORCID: https://orcid.org/0000-0001-9735-4160)
- S. Buabbas
- Balasubramanian Venkatesh (ORCID: https://orcid.org/0000-0002-3234-5244)
- Pascal Stammet (ORCID: https://orcid.org/0000-0002-0298-1012)
- Brian Crichton
- Jenny Cole
- Alan Williams (ORCID: https://orcid.org/0000-0003-3383-5058)
- Ville Niemelä (ORCID: https://orcid.org/0009-0009-5048-4801)
- Philipp Seidel
- Alistair D. Nichol (ORCID: https://orcid.org/0000-0002-4771-5615)
- Peter McGuigan
- T. Oksanen
- A Stewart
Institutions
- University College Dublin (IE)
- Queen's University Belfast (GB)
- Oslo University Hospital (NO)
- The University of Sydney (AU)
- Karolinska University Hospital (SE)
- University of Helsinki (FI)
- University of Ulster (GB)
- Innsbruck Medical University (AT)
- Queensland University of Technology (AU)
- Centre Hospitalier de Luxembourg (LU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- National University of Singapore (SG)
- Nanyang Technological University (SG)
- University of Eastern Finland (FI)
- University of Southern Denmark (DK)
- King's College London (GB)
- King Saud bin Abdulaziz University for Health Sciences (SA)
- University of Luxembourg (LU)
- Lund University (SE)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Charles University (CZ)
- Barts Health NHS Trust (GB)
- Oulu University Hospital (FI)
- Leeds Teaching Hospitals NHS Trust (GB)
- Royal Brisbane and Women's Hospital (AU)
- Kantonsspital St. Gallen (CH)
- Royal North Shore Hospital (AU)
- Stavanger University Hospital (NO)
- Helsinki University Hospital (FI)
- Middlemore Hospital (NZ)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Liverpool Hospital (AU)
- University Hospital of Wales (GB)
- Jorvi Hospital (FI)
- University Hospital of Bern (CH)
- Wellington Hospital (NZ)
- Ghent University Hospital (BE)
- The Alfred Hospital (AU)
- Tan Tock Seng Hospital (SG)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Christchurch Hospital (NZ)
- Karolinska Institutet (SE)
- UNSW Sydney (AU)
- Wroclaw Medical University (PL)
- Humboldt-Universität zu Berlin (DE)
- Australian and New Zealand Intensive Care Society (AU)
- Portsmouth Hospitals NHS Trust (GB)
- Kuopio University Hospital (FI)
- North Estonia Medical Centre (EE)
- King Abdullah International Medical Research Center (SA)
- Azienda Unità Sanitaria Locale di Ferrara (IT)
- University Hospital of Zurich (CH)
- Lovisenberg Diakonale Høgskole (NO)
- The George Institute for Global Health (AU)
- King's College Hospital NHS Foundation Trust (GB)
- Luxembourg Institute of Science and Technology (LU)
- Azienda Ospedaliera Santa Maria Degli Angeli (IT)
- University Hospital Schleswig-Holstein (DE)
- Essex Cardiothoracic Centre (GB)
- St. Vincent's University Hospital (IE)
- Department of Physiological Sciences (RU)
- Epatocentro Ticino (CH)
- St George Hospital (AU)
- Tampere University Hospital (FI)
- German Centre for Cardiovascular Research (DE)
- Royal Victoria Hospital (GB)
- Al-Sabah Hospital (KW)
- Helsingborgs lasarett (SE)
- Tampere University (FI)
- Medical Research Institute of New Zealand (NZ)
- Skåne University Hospital (SE)
- Hertie Institute for Clinical Brain Research (DE)
- Ingham Institute (AU)
- Ospedale Policlinico San Martino (IT)
- Ziekenhuis Oost-Limburg (BE)
- Innovation Skåne (Sweden) (SE)
- George Institute for Global Health (CN)
- Hallands sjukhus Halmstad (SE)
- General University Hospital in Prague (CZ)
- South Western Sydney Local Health District (AU)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
- Anglia Ruskin University (GB)
- Monash University (AU)
- Charité - Universitätsmedizin Berlin (DE)
- University of Gothenburg (SE)
- University of Lübeck (DE)
- University of Oulu (FI)
- Macquarie University (AU)
Publication Details
- Journal
- Acta Anaesthesiologica Scandinavica
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1111/aas.70022
- Citations
- 14
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 31.55
Funders
- Medicinska Understödsföreningen Liv och Hälsa
- Laerdal Foundation for Acute Medicine
- Vetenskapsrådet
- Sigrid Juséliuksen Säätiö
- Xenios
- Sphingotec GmbH
- Medical Research Council
- National Health and Medical Research Council
- Health Research Council of New Zealand