Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival
This study demonstrated a causal relationship between allopurinol use and an increased risk of HCC based on genetic evidence. Allopurinol should be used with caution in patients with or at risk for HCC.
Authors
- Huiwei Wang (ORCID: https://orcid.org/0000-0002-7024-4153)
- Yufu Li (ORCID: https://orcid.org/0000-0002-6792-9880)
- Yuan Meng (ORCID: https://orcid.org/0009-0003-3001-5799)
- Dongye Yang (ORCID: https://orcid.org/0000-0003-3558-8871)
- Zhenying Zhang (ORCID: https://orcid.org/0000-0003-4452-2954)
- Haichuan Peng (ORCID: https://orcid.org/0000-0003-4699-4568)
- Zhao Yao (ORCID: https://orcid.org/0009-0003-5483-4385)
Institutions
- University of Hong Kong - Shenzhen Hospital (CN)
- Shenzhen University Health Science Center (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1007/s12672-025-02176-0
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science, Technology and Innovation Commission of Shenzhen Municipality
- Medical Research Council