Bronchopulmonary dysplasia: signatures of monocyte-macrophage reactivity and tolerance define novel placenta-lung endotypes
Bronchopulmonary dysplasia is a complex, multifactorial chronic lung disease in which the mechanisms of placenta-lung crosstalk are poorly understood. This study uses novel AI approaches to understand how fetal monocytes and lung macrophages contribute to the pathogenesis of BPD. The study identified changes in macrophage reactivity versus tolerance that could explain the heterogeneity and adaptability of immune cells and the placenta in modulating health and disease in the developing fetus and neonate.
Authors
- Karen K. Mestan (ORCID: https://orcid.org/0000-0002-8506-784X)
- Sonalisa Pandey
- Lawrence S. Prince (ORCID: https://orcid.org/0000-0002-7010-4548)
- Sarah Lazar (ORCID: https://orcid.org/0000-0002-9932-8916)
- Louise C. Laurent (ORCID: https://orcid.org/0000-0002-2095-7534)
- Abhineet M. Sharma
- Mana M. Parast (ORCID: https://orcid.org/0000-0001-5963-2246)
- Debashis Sahoo (ORCID: https://orcid.org/0000-0003-2329-8228)
Institutions
- University of Nebraska at Omaha (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- University of Nebraska Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1038/s41390-025-04025-w
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Institutes of Health
- University of California, San Diego
- National Heart, Lung, and Blood Institute
- School of Medicine, University of California, San Diego