Cerebello‐Prefrontal Connectivity Underlying Cognitive Dysfunction in Spinocerebellar Ataxia Type 2
Our findings demonstrated that SCA2 patients have an increase in beta cerebello-prefrontal connectivity that correlates with cognitive performance. These findings suggest cerebello-cortical EEG could track circuit dysfunction underlying cognitive symptoms in SCA2, paving the way for developing targeted neuromodulation therapeutics.
Authors
- Ming‐Kai Pan (ORCID: https://orcid.org/0000-0001-5535-2714)
- Ami Kumar
- Sheng‐Han Kuo (ORCID: https://orcid.org/0000-0002-9412-931X)
- Ruo‐Yah Lai (ORCID: https://orcid.org/0000-0003-0371-583X)
- Yi‐Cheng Lin (ORCID: https://orcid.org/0000-0002-5130-5280)
- Priti I. Parekh
- Zena Fadel
- Rachel Griep
Institutions
- National Taiwan University (TW)
- Taipei Veterans General Hospital (TW)
- Institute of Biomedical Sciences, Academia Sinica (TW)
- National Taiwan University Hospital (TW)
- Columbia University (US)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1002/acn3.70028
- Citations
- 2
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Brain Research Foundation
- National Ataxia Foundation
- International Essential Tremor Foundation
- Parkinson's Foundation
- National Science Council
- Academia Sinica
- National Health Research Institutes
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke