Causal Relationship between Omega-6/Omega-3 Fatty Acid Ratio and Risk of Lung Cancer: A Mendelian Randomization Study Base on A European Cohort
28 SNPs related to Omega-6/Omega-3 fatty acid ratio were selected as IVs in total. The MR analyses results showed that higher Omega-6/Omega-3 fatty acid ratio was associated with lower risk of lung cancer (<i>P</i> = 0.009). No statistical significance was observed for MR-Egger and simple mode methods (<i>P</i> > 0.05). No significant horizontal pleiotropy was detected by MR-Egger regression test (<i>P</i> = 0.73). Conclusion: Higher Omega-6/Omega-3 fatty acid ratio was associated with lower lung cancer risk.
Authors
- Guanqiang Yan (ORCID: https://orcid.org/0009-0000-2089-4556)
- Guiyu Feng (ORCID: https://orcid.org/0000-0003-3345-7026)
- Zhanyu Xu (ORCID: https://orcid.org/0000-0002-6471-1667)
- Hua‐Fu Zhou (ORCID: https://orcid.org/0000-0002-2267-3164)
- Yue Li (ORCID: https://orcid.org/0009-0008-0483-4789)
- Longqian Wei
- Jun Liu (ORCID: https://orcid.org/0000-0003-3671-3208)
- Xiang Gao (ORCID: https://orcid.org/0000-0003-2617-6509)
- Guosheng Li (ORCID: https://orcid.org/0009-0003-8478-1616)
- Nuo Yang (ORCID: https://orcid.org/0009-0006-4623-8913)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Nutrition and Cancer
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1080/01635581.2025.2486151
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00