Chemical constituents from <i>Calophyllum polyanthum</i> and their biological activity

Phytochemical investigation of <i>Calophyllum polyanthum</i> led to the isolation of six xanthones, six chromanone derivatives, one coumarin, one glycoside and one flavonoid, including two new xanthones named caledonixanthone M (<b>1</b>), caledonixanthone N (<b>2</b>) and thirteen known compounds (<b>3-15</b>). Among them, the structures of <b>1</b> and <b>2</b> were elucidated by analysis of spectroscopic data. Some known compounds showed potent <i>α</i>-glucosidase inhibitory and cytotoxic activity. Especially, compound <b>14</b> showed moderate inhibitory activities on <i>α</i>-glucosidase with IC₅₀ value of 79.41 ± 0.22 µM, and compound <b>5</b> displayed anticancer effect on A549 non-small cell lung cancer cells.