Formulation optimization and characterization of Central composite design optimized LAP-loaded calcium pectinate nanoparticles: anticancer activity against MCF-7 cells
The study successfully developed and optimized LAP-PEC-NPs, yielding nanoparticles with desirable characteristics. The sustained drug release kinetics and promising anticancer efficacy of LAP-PEC-NPs suggest their potential as a therapeutic strategy for breast cancer treatment. These findings pave the way for further preclinical and clinical studies to validate the efficacy and safety of LAP-PEC-NPs for clinical translation.
Authors
- Leander Corrie
- Abhishek Verma (ORCID: https://orcid.org/0000-0002-2374-5254)
- Raj Kamal (ORCID: https://orcid.org/0000-0002-7138-6313)
- Ankit Awasthi (ORCID: https://orcid.org/0000-0002-3266-7649)
- Shubham Thakur (ORCID: https://orcid.org/0000-0001-5857-2624)
- Manish Kumar (ORCID: https://orcid.org/0000-0003-2042-1243)
- Milan Singh Kahlon
- Abhishek Chauhan (ORCID: https://orcid.org/0000-0002-1138-4551)
Institutions
- Chitkara University (IN)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-04-04
- DOI
- https://doi.org/10.1080/03639045.2025.2485311
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00