Spatial Profiling Identifies Regionally Distinct Microenvironments and Targetable Immunosuppressive Mechanisms in Pediatric Osteosarcoma Pulmonary Metastases
Exploration of spatially resolved microenvironments in metastatic osteosarcoma tissues reveals how the tissue architecture promotes immunosuppression and identifies actionable processes to enhance immunotherapy efficacy.
Authors
- Jennifer Cotter (ORCID: https://orcid.org/0000-0002-1420-3314)
- Amy K. LeBlanc (ORCID: https://orcid.org/0000-0001-7656-9859)
- Michael C. Kelly (ORCID: https://orcid.org/0000-0003-0654-2778)
- Monica Mendez
- Nathan Wong (ORCID: https://orcid.org/0000-0002-8882-3401)
- Jessica A. Beck (ORCID: https://orcid.org/0000-0002-0145-7606)
- Rosandra N. Kaplan (ORCID: https://orcid.org/0000-0002-8580-0001)
- Julie Galindo
- James C. Cronk (ORCID: https://orcid.org/0000-0001-6401-0740)
- Demond Williams
- Paul Mallory (ORCID: https://orcid.org/0000-0003-2266-2577)
- Janice S. Pereira (ORCID: https://orcid.org/0009-0009-7819-4566)
- Ashley Cardamone
- Milind Pore (ORCID: https://orcid.org/0000-0001-6513-653X)
- Linus Kaiser
- Carly M. Sayers (ORCID: https://orcid.org/0000-0001-8554-0281)
- Troy A. McEachron (ORCID: https://orcid.org/0000-0003-0695-5783)
- Jatinder Singh
- Jason Eigenbrood
- Douglass W. Morris-II
Institutions
- University of Southern California (US)
- National Institutes of Health (US)
- Children's Hospital of Los Angeles (US)
- Cancer Research UK Cambridge Center (GB)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1158/0008-5472.can-24-3723
- Citations
- 8
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 8.36