<scp>mRNA</scp> – <scp>miRNA</scp> integration analysis of T‐cell exhaustion in sepsis from community‐acquired pneumonia
This study provides valuable insights into the molecular mechanisms underlying CAP-associated sepsis, confirming the occurrence of immune dysregulation, particularly T-cell exhaustion. Our findings suggest that specific miRNAs and signaling pathways identified here may serve as potential therapeutic targets or biomarkers.
Authors
- Daisuke Okuzaki (ORCID: https://orcid.org/0000-0002-4552-783X)
- Shinya Onishi (ORCID: https://orcid.org/0000-0003-0126-2320)
- Jumpei Yoshimura (ORCID: https://orcid.org/0000-0002-4092-8140)
- Jun Oda (ORCID: https://orcid.org/0000-0002-8254-3716)
- Yumi Mitsuyama (ORCID: https://orcid.org/0000-0002-6272-6910)
- Hiroshi Ogura (ORCID: https://orcid.org/0000-0002-5013-2445)
- Susumu Tanaka (ORCID: https://orcid.org/0000-0002-0306-3627)
- Hiroshi Itô (ORCID: https://orcid.org/0000-0003-1029-5730)
- Arisa Muratsu (ORCID: https://orcid.org/0000-0002-7035-7684)
- Yuki Togami
- Sayaka Oda
- Hisatake Matsumoto
Institutions
- Osaka Dental University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Acute Medicine & Surgery
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/ams2.70054
- Citations
- 2
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Japan Agency for Medical Research and Development