Targeting PDK1: A novel approach to combat hypoxia‐induced epithelial‐mesenchymal transition in chronic rhinosinusitis with nasal polyps
This study is the first to reveal that hypoxia-induced activation of PDK1 plays a critical role in regulating EMT by promoting lactate production, thereby providing a potential therapeutic target for CRSwNP.
Authors
- Mengyan Zhuang
- Luo Zhang (ORCID: https://orcid.org/0000-0002-0910-9884)
- Y C Li (ORCID: https://orcid.org/0009-0003-0179-2660)
- Qinqin Zhang (ORCID: https://orcid.org/0000-0002-3925-3211)
- Ting He (ORCID: https://orcid.org/0000-0002-2856-9501)
- Jian Jiao (ORCID: https://orcid.org/0000-0002-6291-820X)
- Xiangdong Wang
- Sicen Pan
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
- Beijing Municipal Education Commission (CN)
Publication Details
- Journal
- Clinical and Translational Allergy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/clt2.70048
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Municipal Health Commission