Ketamine's Influence on Magnetoencephalography Patterns During a Working Memory Task in Treatment‐Resistant Depression: An Exploratory Study
Despite robust antidepressant effects, ketamine did not affect working memory, attention, or concentration. However, distinct gamma power changes in brain regions linked to attention and working memory highlight the need to further explore the neurobiological mechanisms underlying ketamine's cognitive effects in TRD. Future research with larger samples, broader cognitive batteries, and repeated ketamine infusions are needed to fully elucidate ketamine's cognitive effects in individuals with TRD.
Authors
- Jessica R. Gilbert (ORCID: https://orcid.org/0000-0002-4194-6172)
- Carlos Alfonso Tovilla‐Zárate (ORCID: https://orcid.org/0000-0001-8170-8171)
- Abigail Vogeley (ORCID: https://orcid.org/0000-0003-4812-5155)
- Mani Yavi (ORCID: https://orcid.org/0000-0001-8387-4720)
- Adam Fijtman (ORCID: https://orcid.org/0000-0002-7700-4283)
- Dede Greenstein
Institutions
- National Institutes of Health (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- Bipolar Disorders
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/bdi.70027
- Citations
- 2
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institute of Mental Health