Unravelling the genetic contributors to linezolid resistance in <i>Mycobacterium smegmatis</i>: insights from a transposon library
The research successfully identified two genes, MSMEG_4189 and MSMEG_0965, associated with linezolid resistance in M. smegmatis. It also elucidated the role of MSMEG_0965 in the resistance mechanism, providing significant targets and reference points for future studies on clinical strains.
Authors
- Yuanyi Zhang (ORCID: https://orcid.org/0000-0002-2609-5672)
- Zhifei Luo (ORCID: https://orcid.org/0000-0002-4691-8074)
- Jing Wang (ORCID: https://orcid.org/0000-0001-8628-8452)
- Xinchun Chen (ORCID: https://orcid.org/0000-0002-2101-9013)
- Dachuan Lin (ORCID: https://orcid.org/0000-0002-4404-7391)
Institutions
- Xinjiang Medical University (CN)
- Shenzhen University (CN)
- Hainan Medical University (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-03-20
- DOI
- https://doi.org/10.1093/jac/dkaf106
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Key Research and Development Program of China
- Basic and Applied Basic Research Foundation of Guangdong Province