Associations of Serum Inflammatory Biomarkers During Pregnancy With Placental Pathology and Placental Gene Expression at Delivery
Our results indicate that elevated maternal circulating IL-10 during pregnancy is associated with chronic inflammatory lesions in the placenta at delivery. Additionally, higher levels of circulating IL-10 are associated with upregulated STAT signaling pathways in placental tissues.
Authors
- Gregory E. Miller (ORCID: https://orcid.org/0000-0002-7217-1082)
- Steve Cole
- Amy Crockett (ORCID: https://orcid.org/0000-0001-9630-3716)
- Alexa A. Freedman (ORCID: https://orcid.org/0000-0001-9745-7768)
- Linda M. Ernst (ORCID: https://orcid.org/0000-0003-0104-5107)
- Ann Borders (ORCID: https://orcid.org/0000-0003-3373-0619)
- Lauren Keenan‐Devlin (ORCID: https://orcid.org/0000-0002-7908-2971)
- Renee M. Odom‐Konja
Institutions
- Northwestern University (US)
- Prisma Health (US)
- University of California, Los Angeles (US)
- University of Chicago (US)
- Evanston Hospital (US)
Publication Details
- Journal
- American Journal of Reproductive Immunology
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1111/aji.70062
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Heart, Lung, and Blood Institute
- Eunice Kennedy Shriver National Institute of Child Health and Human Development