Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC<sub>50</sub> value of 4.24 ± 0.13 μM, more than the positive control drug (12.99 ± 0.13 μM).

Authors

Institutions

Publication Details

Journal
Natural Products and Bioprospecting
Published
2025-04-03
DOI
https://doi.org/10.1007/s13659-025-00503-0
Citations
8
Primary Topic
Microbial Natural Products and Biosynthesis
Type
article
Field-Weighted Citation Impact
11.16

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

Fang-Yu Yuan, Xun Wei, Gui‐Hua Tang, Zhang‐Hua Sun et al.
8 citations
Natural Products and Bioprospecting
Microbial Natural Products and Biosynthesis
11.16
article

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1

Fang-Yu Yuan, Xun Wei, Gui‐Hua Tang, Zhang‐Hua Sun, Yifan Fu, Wei Wu, Qiong Liao, Leiming Wu, Lei Li, Dong Huang, Qing-Ren Lu, Tao Yuan, Shuqi Wu
article en
8 citations

Abstract

A series of structurally diverse polyketides (1-3), sesterterpenoids (24 and 25), and alkaloids (26-34) were isolated from the fermentation of a plant-derived fungus Penicillium canescens L1 on solid rice medium. Among these secondary metabolites, penicanesols A-G (1-7) were new structures, which were elucidated by NMR, HR-ESI-MS, ECD calculation, and X-ray diffraction. Penicanesol A (1) represented a rare dimer derived from phthalan derivatives, characterized by a 5/6/6/6/5 heteropentacyclic core. The bioassay on the NCI-H1975 cell model showed that two compounds had good cytotoxic activities, and the most significant activate compound 13 had an IC<sub>50</sub> value of 4.24 ± 0.13 μM, more than the positive control drug (12.99 ± 0.13 μM).

Natural Products and BioprospectingVol. 15(1)
Sun Yat-sen University (CN), Shaoguan University (CN), Jiangxi Normal University (CN)
National Natural Science Foundation of China, Science and Technology Planning Project of Guangdong Province, Basic and Applied Basic Research Foundation of Guangdong Province
Openalex Percentile: Top 1%
Microbial Natural Products and Biosynthesis
11.16
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1 — Fang-Yu Yuan, Xun Wei, et al. · Natural Products and Bioprospecting (2025) | TGRS Research Map | TGRS