Diuretic effect and renal function impact of dapagliflozin in hospitalized patients with HFrEF.
In hospitalized patients with chronic HFrEF, dapagliflozin treatment increased 24-hour average difference of liquid intake and output and total urine output, reduced NT-proBNP levels, and showed a milder decline in eGFR in those with pre-existing renal impairment. Discharge blood pressure, drug costs, and hospital stay were not significantly affected. While standard therapy may offer better short-term clinical benefits, dapagliflozin demonstrated a superior short-term cost-effectiveness profile.
Authors
- Ke Xia (ORCID: https://orcid.org/0000-0001-9699-9901)
- Pingsheng Xu (ORCID: https://orcid.org/0000-0003-0183-7649)
- Huijun Liu (ORCID: https://orcid.org/0000-0003-0438-725X)
- Dai Li (ORCID: https://orcid.org/0000-0002-1720-5542)
- Xiaolei Hu (ORCID: https://orcid.org/0000-0002-4811-9954)
- Xiaoxiao Mao
- Shanshan Li (ORCID: https://orcid.org/0000-0002-1888-8998)
- Youxuan Wu
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-28
- DOI
- https://doi.org/10.11817/j.issn.1672-7347.2024.240294
- Primary Topic
- Biomedical Research and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00