Oppositely biased glucagon‐like peptide‐1 receptor agonism does not differentially affect lipid metabolism in <scp>APOE</scp> *3‐Leiden CETP mice
The oppositely biased GLP-1 receptor agonists acyl-ExD3 and acyl-ExF1 do not differentially affect lipid metabolism in APOE*3-Leiden.CETP mice, while effects on glucose homeostasis and prevention of body weight gain are more pronounced upon peripheral acyl-ExF1 treatment.
Authors
- Salwa Afkir
- Sander Kooijman (ORCID: https://orcid.org/0000-0002-0014-5571)
- Patrick C.N. Rensen (ORCID: https://orcid.org/0000-0002-8455-4988)
- Amanda C. M. Pronk
- Trea C.M. Streefland
- Robin van Eenige (ORCID: https://orcid.org/0000-0003-2637-3801)
- Ben Jones (ORCID: https://orcid.org/0000-0003-0461-2584)
- Melanie Modder (ORCID: https://orcid.org/0000-0002-8715-1586)
- Alejandra Tomás (ORCID: https://orcid.org/0000-0002-2290-8453)
- Reshma A. Lalai
Institutions
- Leiden University Medical Center (NL)
- Imperial College London (GB)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1111/dom.16374
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00