Exercise training restores longevity‐associated tryptophan metabolite 3‐hydroxyanthranilic acid levels in middle‐aged adults
We translate the association between systemic 3-HAA levels and age from animal models into humans and highlight longer-term exercise training as an efficient strategy to boost systemic 3-HAA levels in middle-aged adults. Our findings open promising research avenues concerning the mediating role of 3-HAA in training adaptations, health, and longevity.
Authors
- Adrian McCann (ORCID: https://orcid.org/0000-0002-5728-5321)
- Niklas Joisten (ORCID: https://orcid.org/0000-0002-9947-8746)
- Philipp Zimmer (ORCID: https://orcid.org/0000-0001-9631-4503)
- Per Magne Ueland (ORCID: https://orcid.org/0000-0002-1903-0571)
- Andreas Venhorst (ORCID: https://orcid.org/0000-0002-9793-6985)
- Tim Meyer (ORCID: https://orcid.org/0000-0003-3425-4546)
- Friederike Rosenberger (ORCID: https://orcid.org/0000-0002-4147-2958)
- David Walzik (ORCID: https://orcid.org/0000-0002-9577-1435)
- Alexander Schenk (ORCID: https://orcid.org/0000-0002-3122-714X)
- Marcel Reuter (ORCID: https://orcid.org/0009-0006-4778-3657)
- Marie Kupjetz (ORCID: https://orcid.org/0000-0002-1816-8595)
Institutions
- TU Dortmund University (DE)
- Deutsche Hochschule für Prävention und Gesundheitsmanagement (DE)
- Bevital (Norway) (NO)
- University of Göttingen (DE)
- Saarland University (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1111/apha.70041
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16