Multi-tissue metabolomics analysis reveals susceptible factors for chemotherapy-induced hepatotoxicity in colorectal cancer patients
This study emphasizes the critical role of alterations in lipid, polyamine, and purine metabolism, as well as impaired tissue repair mechanisms, were identified as key endogenous factors underlying CIH susceptibility. The developed predictive models demonstrate potential for clinical application in assessing CIH risk in CRC patients undergoing CAPEOX chemotherapy.
Authors
- Shi Qiu (ORCID: https://orcid.org/0000-0003-4304-222X)
- Hong Yang (ORCID: https://orcid.org/0000-0002-2232-1847)
- Houshan Yao (ORCID: https://orcid.org/0000-0002-8966-3411)
- Jiawei Zhu (ORCID: https://orcid.org/0000-0001-5708-6704)
- Xuan Liu (ORCID: https://orcid.org/0000-0001-5325-0685)
- Tao Xia (ORCID: https://orcid.org/0000-0003-3014-4825)
- X. Hou
- Zhipeng Wang (ORCID: https://orcid.org/0000-0002-7964-9288)
- Zeshuai Lin
- Rong Wang (ORCID: https://orcid.org/0000-0002-0225-1191)
- Mingming Li (ORCID: https://orcid.org/0000-0003-0621-6227)
- Lei Liu (ORCID: https://orcid.org/0000-0003-0256-0944)
- Huilin Xu (ORCID: https://orcid.org/0000-0002-1983-0413)
- Jiani Chen (ORCID: https://orcid.org/0000-0002-0408-1798)
- Chun-Shu Yu
- Guoliang Chen (ORCID: https://orcid.org/0000-0003-3391-4813)
Institutions
- National Institute for Parasitic Diseases (CN)
- Second Military Medical University (CN)
- Fudan University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Changzheng Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fphar.2025.1517446
- Citations
- 1
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Fudan University
- National Key Research and Development Program of China