An efficient one-pot synthesis, bioassay of 7, 7-Dimethyl-4-phenyl-2-thioxo-2, 3, 4, 6, 7, 8- hexahydro-1H-quinazolin-5-ones Promoted PPh3 as a catalyst

A straight forward one pot three component synthesis of seven novel derivatives 7, 7-dimethyl-4-phenyl-2-thioxo-2,3,4, 6, 7, 8-hexahydro-1H-quinazolin-5-one by a cyclocondensation of dimedone and substitutes aromatic aldehyde with thiourea in the presence of PPh3 as a catalyst with to good yields. All structures of products were confirmed by 1H NMR and 13C NMR spectroscopy. The antibacterial activity of some synthesized compounds was investigated against Staphylococcus aureus), Staphylococcus epidermidis, Bacillus cereus, Esherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa bacteria. Some of these compounds exhibited a good to significant antibacterial activity. . KEYWORDS: Dimedone, substitutedarylaldehydes,7,7-Dimethyl-4-phenyl-2-thioxo-1,2,3,4,6,7,8-hexahydro-1H-quinazolin-5-ones , PPh3, antibacterial activity