Methotrexate Toxicity - A Case Report

This case study studies the adverse effect of methotrexate toxicity and the importance of early recognition of the sign and symptoms of methotrexate toxicity. This study involves a 61- years old male patient who took excessive intake of tablet methotrexate (10mg/day) for 1 week. The patient was diagnosed with known case of Psoriasis, was then seen by his primary care physician and surgeon opinion for hemorrhagic back ulcers. At this time patient was complaining of Hemorrhagic plaque all over the body and oral ulcers, throat pain, painful lesions and a repeat of complete blood picture (CBP), and platelet count demonstrated Thrombocytopenia. The patient was admitted to the hospital for further management or treatment of methotrexate toxicity. MTX which is used for Rheumatoid Arthritis treatment/management, causes thrombocytopenia. Methotrexate is one of the most widely used systematic immunosuppressive agents in dermatology. Keywords: Methotrexate, Thrombocytopenia, Hemor-rhagic ulcers.