Endothelium- and Fibroblast-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Aortic Aneurysm
Endothelium- and fibroblast-derived CNP, via NPR-C activation, plays important roles in attenuating AA formation by preserving aortic structure and function. Therapeutic strategies aimed at mimicking CNP bioactivity hold potential to reduce the need for surgical intervention.
Authors
- J S Sanghera
- Aisah A. Aubdool (ORCID: https://orcid.org/0000-0002-4712-9421)
- Scott A. LeMaire (ORCID: https://orcid.org/0000-0002-8736-4266)
- Reshma S. Baliga (ORCID: https://orcid.org/0000-0002-5582-5152)
- Ying H. Shen (ORCID: https://orcid.org/0000-0003-4119-115X)
- Hong Lü (ORCID: https://orcid.org/0000-0002-0577-2558)
- Cristina Pérez‐Ternero (ORCID: https://orcid.org/0000-0002-2349-0642)
- Adrian J. Hobbs (ORCID: https://orcid.org/0000-0002-3589-7108)
- Atinder Panesar
- Alan Daugherty (ORCID: https://orcid.org/0000-0003-2093-3775)
- Janice C S Tsui (ORCID: https://orcid.org/0000-0001-6826-4211)
- Ziad Mallat (ORCID: https://orcid.org/0000-0003-0443-7878)
- Amie J. Moyes (ORCID: https://orcid.org/0000-0001-9336-9904)
- Yanming Li (ORCID: https://orcid.org/0000-0002-8213-9166)
- Mohammed Syed
- Hernan G. Vasquez
- Juliette Raffort-Lareyre
- Kareemah Jaigirdah
Institutions
- Geisinger Medical Center (US)
- University of Kentucky (US)
- Inserm (FR)
- Queen Mary University of London (GB)
- Royal Free London NHS Foundation Trust (GB)
- Baylor College of Medicine (US)
- Lung Institute (US)
- Geisinger Neuroscience Institute (US)
- University College London (GB)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1161/atvbaha.124.322350
- Citations
- 4
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07