Colchicine Inhibits Smooth Muscle Cell Phenotypic Switch and Aortic Dissection in Mice—Brief Report
This study identifies colchicine as a potential therapeutic drug for AD, highlighting its ability to mitigate hallmark pathological processes such as vascular inflammation and VSMC phenotypic switch. These findings offer a foundation base for the repurposed clinical application of colchicine in AD, which warrants further clinical investigation.
Authors
- Hongfang Jin (ORCID: https://orcid.org/0000-0002-1606-8988)
- Xiang Cheng (ORCID: https://orcid.org/0000-0002-6287-3128)
- Yaping Zhao (ORCID: https://orcid.org/0009-0006-5017-342X)
- Jianping Weng (ORCID: https://orcid.org/0000-0002-7889-1697)
- Suowen Xu (ORCID: https://orcid.org/0000-0002-5488-5217)
- Li Wang (ORCID: https://orcid.org/0000-0002-3377-8092)
- Zhiping Liu (ORCID: https://orcid.org/0000-0001-7272-6917)
- Yü Huang (ORCID: https://orcid.org/0000-0002-1277-6784)
- Hui Jiang (ORCID: https://orcid.org/0000-0003-1401-3227)
- Zhidan Zhang
Institutions
- University of Science and Technology of China (CN)
- Jinan University (CN)
- City University of Hong Kong (HK)
- Wuhan Union Hospital (CN)
- Anhui Provincial Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1161/atvbaha.124.322252
- Citations
- 3
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 4.56