Relationship Between Histomorphological Typing And Immunohistochemistry Expression Of Breast Prognostic Markers (ER, PR, Her2neu) In Breast Carcinoma At A Tertiary Care Hospital

Background: Breast cancer remains the most prevalent cancer in Indian women. The histopathological examination by morphology, accompanied by the recommendation to assess hormone receptors—specifically Estrogen Receptor (ER), Progesterone Receptor (PR), and HER2—by the College of American Pathologists and the American Society of Clinical Oncology, are widely recommended due to their prognostic and therapeutic values. Immunohistochemical characterization and gene examination are also essential, as cumulative results reveal the importance of hormone receptors in breast cancer. This study aims to retrospectively analyze the positivity rate of hormone receptors and HER2 in breast cancer patients. Materials and Methods: The study, conducted over three years, included 51 cases of breast carcinoma, managed at Sharda Hospital, Sharda University. Samples were tested through immunohistochemistry against ER, PR, and HER2, citing ASCO/CAP Guidelines. The results were correlated with clinicopathological and histopathological data. Results: ER and PR expression were proportionally greater in younger patients (<50 years), similar to HER2. A significant correlation of ER and PR was observed with increasing tumor grade, with p-values of 0.0115 and 0.0378, respectively. No significant correlation was found for Her2neu with tumor grade, with nodal status, or with age/menopausal status. ER and PR involvement significantly decreases as tumor grade increases.