ALKBH5 Regulates Macrophage Senescence and Accelerates Atherosclerosis by Promoting CCL5 m <sup>6</sup> A Modification
Myeloid ALKBH5 deletion attenuates atherosclerosis progression by suppressing the formation of senescent foamy macrophages and the recruitment of CD8<sup>+</sup>IFNγ<sup>+</sup> T cells. These findings identify ALKBH5, CCL5, and CCR5 as novel therapeutic targets for atherosclerosis.
Authors
- Xi Sun (ORCID: https://orcid.org/0009-0004-7844-9753)
- Jiaran Shi (ORCID: https://orcid.org/0000-0002-2020-0830)
- Juntao Chen (ORCID: https://orcid.org/0000-0003-4376-2390)
- Bichen Ren (ORCID: https://orcid.org/0000-0002-6021-0208)
- Kun Yang (ORCID: https://orcid.org/0000-0001-7908-2675)
- Rifeng Gao (ORCID: https://orcid.org/0000-0002-5453-8899)
- Jun Jiang (ORCID: https://orcid.org/0000-0001-6926-9516)
- Yang Lyu (ORCID: https://orcid.org/0000-0002-4353-0082)
- Wei Wei (ORCID: https://orcid.org/0000-0002-2234-4459)
- Bo Li (ORCID: https://orcid.org/0000-0001-9476-3073)
- Jianxin Chen (ORCID: https://orcid.org/0000-0003-4067-5638)
- Yan Zhou (ORCID: https://orcid.org/0000-0001-9402-1109)
- Jiahui Cheng (ORCID: https://orcid.org/0009-0004-0932-8245)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
- Shanghai Chest Hospital (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai Traditional Chinese Medicine Hospital (CN)
- Ministry of Education (TW)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1161/atvbaha.125.322508
- Citations
- 10
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 8.06