The Correlation of Diagnostic Accuracy For The Endometrial Lesions Between Aspiration Cytology, Cell Block Preparation and Histopathology -An Overview

Background: Accurately diagnosing malignant tumors is a key function of endometrial cytology. In certain cases, the endometrial cytology alone cannot diagnose endometrial malignancies. In such cases, an invasive procedure, endometrial tissue collection is necessary to validate the final diagnosis. Material & Methods: Keywords and tools were used to search the related articles in the main electronic databases. The keywords and tools adopted for the search ensured a comprehensive and systematic approach to search for the articles reviewing necessity for endometrial tissue biopsy as a definitive method Results and discussions: The insights gained from this overview provide a foundation for future research about the cytology and cell block preparation of endometrial aspirate to be reliable and accurate screening tool for endometrial lesions. The cytology is a cost-effective procedure and it has the extra benefit of not requiring anesthesia during the acquisition of sample from patients while the other procedures have issues including perforation. Conclusions: Amongst perimenopausal and post- menopausal women presenting with abnormal uterine bleeding (AUB), aspirate cytology and cell block preparation could be considered as primary investigation for screening of early detection of various endometrial diseases especially hyperplasia and malignancy thereby leading to better prognostic outcome and significantly contribute in the reduction of morbidity and mortality.