Electrochemical Cyclization of 2,3-Allenols
An efficient electrochemical bromocyclization of allenols has been realized for the synthesis of spirocyclic 2,5-dihydrofurans. The reaction used commercially available and nontoxic KBr as the brominating source in a simple setup under open-air conditions. Notably, optically active products can be obtained from optically active 2,3-allenols without any racemization, further enhancing the synthetic utility.
Authors
- Zhongshuo Zhang
- Wenyao Li (ORCID: https://orcid.org/0000-0003-3634-2021)
- Ying Wang (ORCID: https://orcid.org/0000-0002-6240-5535)
- Zhuowei Xu (ORCID: https://orcid.org/0009-0002-1661-1351)
- Shengming Ma (ORCID: https://orcid.org/0000-0002-2866-2431)
- Hao Yu
- Dong Huang (ORCID: https://orcid.org/0009-0006-2442-3309)
Institutions
- Chinese University of Hong Kong (HK)
- Chinese Academy of Sciences (CN)
- Fudan University (CN)
- Shanghai Institute of Organic Chemistry (CN)
- State Key Laboratory of Organometallic Chemistry
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1021/acs.orglett.5c00193
- Citations
- 2
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Science and Technology Commission of Shanghai Municipality
- National Key Research and Development Program of China