NovoSorb® Biodegradable Temporising Matrix in reconstruction of acral wounds after excision of cutaneous malignancies

Likewise, the use of BTM on previously irradiated tissues or its durability following adjuvant radiotherapy is not known.Methods: We performed a retrospective review of patients undergoing resection of cutaneous malignancies of the scalp and reconstruction with BTM between February 2020 and February 2024.Reported outcomes included BTM integration, skin graft take, surgical site infection, haematoma, late graft loss, and time to postoperative radiotherapy.Results: 22 patients were included of which 21 (95%) were male, 13 (59%) had squamous cell carcinoma, 6 (27%) melanoma and 3 (14%) basal cell carcinoma.All cases required either primary or subsequent resection down to bone to achieve a negative margin, therefore a skin graft alone was not feasible.Of the remaining patients, 18 (82%) had >80%integration of the BTM and subsequent successful skin graft take.3 (14%) patients developed osteomyelitis, one after BTM application and the others after skin grafting.Of the 4 patients who received adjuvant radiotherapy, 2 developed osteoradionecrosis (ORN) (50%).One patient had radiotherapy prior to BTM application, resulting in ORN.In this patient the BTM failed to integrate and they proceeded to have a free-tissue flap.Conclusions: BTM is a reliable adjunct for the reconstruction of complex scalp wounds following resection of cutaneous malignancies, which cannot be managed with skin grafting alone.However, in patients who have previously-or are likely to undergo radiotherapy to their scalp wounds, BTM appears to be less effective.

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Publication Details

Journal
EJC Skin Cancer
Published
2025-01-01
DOI
https://doi.org/10.1016/j.ejcskn.2025.100596
Primary Topic
Nonmelanoma Skin Cancer Studies
Type
article
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article

NovoSorb® Biodegradable Temporising Matrix in reconstruction of acral wounds after excision of cutaneous malignancies

Elan Novis, Michael Rtshiladze
EJC Skin Cancer
Nonmelanoma Skin Cancer Studies
article

NovoSorb® Biodegradable Temporising Matrix in reconstruction of acral wounds after excision of cutaneous malignancies

Elan Novis, Michael Rtshiladze
article en

Abstract

Likewise, the use of BTM on previously irradiated tissues or its durability following adjuvant radiotherapy is not known.Methods: We performed a retrospective review of patients undergoing resection of cutaneous malignancies of the scalp and reconstruction with BTM between February 2020 and February 2024.Reported outcomes included BTM integration, skin graft take, surgical site infection, haematoma, late graft loss, and time to postoperative radiotherapy.Results: 22 patients were included of which 21 (95%) were male, 13 (59%) had squamous cell carcinoma, 6 (27%) melanoma and 3 (14%) basal cell carcinoma.All cases required either primary or subsequent resection down to bone to achieve a negative margin, therefore a skin graft alone was not feasible.Of the remaining patients, 18 (82%) had >80%integration of the BTM and subsequent successful skin graft take.3 (14%) patients developed osteomyelitis, one after BTM application and the others after skin grafting.Of the 4 patients who received adjuvant radiotherapy, 2 developed osteoradionecrosis (ORN) (50%).One patient had radiotherapy prior to BTM application, resulting in ORN.In this patient the BTM failed to integrate and they proceeded to have a free-tissue flap.Conclusions: BTM is a reliable adjunct for the reconstruction of complex scalp wounds following resection of cutaneous malignancies, which cannot be managed with skin grafting alone.However, in patients who have previously-or are likely to undergo radiotherapy to their scalp wounds, BTM appears to be less effective.

EJC Skin CancerVol. 3
The University of Sydney (AU), Royal Prince Alfred Hospital (AU), Melanoma Institute Australia (AU), St George Hospital (AU)
Zero hunger
Openalex Percentile: Top 90%
Nonmelanoma Skin Cancer Studies
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NovoSorb® Biodegradable Temporising Matrix in reconstruction of acral wounds after excision of cutaneous malignancies — Elan Novis, Michael Rtshiladze · EJC Skin Cancer (2025) | TGRS Research Map | TGRS