Lessons learned from the COAST (Contemporary Outcomes After cutaneous SCC in Transplant recipients) study: management and outcomes following the first cutaneous squamous cell carcinoma in kidney transplant recipients
years.Outcomes sought over 3 years include local recurrence, locoregional metastases, distant metastases, or death.Results: The UKKCC biobank resides within NHS Greater Glasgow Tissue Biorepository which is a trusted research environment providing access to clinical data.A central pathology review panel ensures consistent tumour staging and supports pathology research.An initial focus on transcriptomics and immune profiling will be followed by other state-of-the-art 'omics' analyses as funding becomes available.The first validation study will involve 400 FFPE cSCC samples of known immune status with 100+ primary cSCC that metastasized.This cohort will be used to validate the recently published 20-gene signature predictive of cSCC metastasis [2].Conclusions: Through the national biobank and advanced research techniques, we aim to identify key molecular drivers, improve prognostic markers, and explore new treatment options for cSCC.With continued support, the UKKCC will play a key role in advancing research and clinical care in cSCC.Datasets will be publicly available, and we welcome collaborators wishing to join this endeavour.
Authors
- Raj Thuraisingham (ORCID: https://orcid.org/0000-0003-2073-9569)
- Jeva Cernova (ORCID: https://orcid.org/0000-0002-6908-2716)
- Erika Wallin
- Buddhika Wijayawickrama
- Adarsh Babu (ORCID: https://orcid.org/0000-0002-1980-803X)
- Corey Archer (ORCID: https://orcid.org/0000-0002-6070-6297)
- Asma Sharif
- Rachel Abbott (ORCID: https://orcid.org/0000-0002-3415-7132)
- Catherine Harwood (ORCID: https://orcid.org/0000-0002-1375-0965)
- Netra Prakash Bhandary (ORCID: https://orcid.org/0000-0002-9783-5033)
- Rubeta Matin (ORCID: https://orcid.org/0000-0002-9695-5412)
- Farid Ullah Shah (ORCID: https://orcid.org/0000-0002-6824-9350)
- Matthew J. Bottomley (ORCID: https://orcid.org/0000-0001-9734-5694)
- N. Muirhead
- John‐Michael Gamble (ORCID: https://orcid.org/0000-0001-6891-8721)
- Shaun Griffin
- P. Bailey
- A. Darvay
- Khalid Nawab (ORCID: https://orcid.org/0000-0002-1824-413X)
- Razna Ahmed (ORCID: https://orcid.org/0000-0002-3493-8991)
- Emilia Peleva (ORCID: https://orcid.org/0000-0002-1783-9860)
- John M. Moriarty (ORCID: https://orcid.org/0000-0001-8108-520X)
- Anthony Owen
- Tom Crisp (ORCID: https://orcid.org/0009-0000-2036-6913)
- M.A. Gauci
- Harry Wakefield
Institutions
- Cardiff and Vale University Health Board (GB)
- North Bristol NHS Trust (GB)
- Queen Mary University of London (GB)
- Barts Health NHS Trust (GB)
- Royal Sussex County Hospital (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- Royal Berkshire Hospital (GB)
- Buckinghamshire Healthcare NHS Trust (GB)
- St Helier Hospital (GB)
- Gloucestershire Hospitals NHS Foundation Trust (GB)
- University of Oxford (GB)
- Sutton Hospital (GB)
- NIHR Surgical Reconstruction and Microbiology Research Centre (GB)
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- EJC Skin Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.ejcskn.2025.100696
- Primary Topic
- Nonmelanoma Skin Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00