Alteration in oxidative/nitrosative disparity and nephroprotective effect of hydroethanolic extract of Ocimum tenuiflorum L. in gentamicin-induced acute kidney injury
The present findings demonstrate the curative efficacy of <i>O. tenuiflorum</i> in gentamicin-induced AKI, probably mediated through phenolic and flavonoid phytoconstituents, antioxidant properties, and down-regulation of inflammatory cytokines. Therefore, future studies may be established to evaluate its efficacy and safety for clinical trials.
Authors
- Kruti Debnath Mandal
- R. Radhika
- Sanjay Kumar Shukla (ORCID: https://orcid.org/0000-0002-4685-5560)
- M. Saminathan
- G.E. Chethan
- Ujjwal Kumar De (ORCID: https://orcid.org/0000-0001-5806-4726)
- Anand Kumar Singh (ORCID: https://orcid.org/0000-0003-3019-5219)
- Priyanka Choudhary
- Mahesh Kumar (ORCID: https://orcid.org/0000-0001-7583-4841)
- Alok Kumar Singh (ORCID: https://orcid.org/0000-0003-0728-7684)
- Neeraj Thakur (ORCID: https://orcid.org/0000-0002-9132-7644)
- Kalyan Sarma
Institutions
- Indian Veterinary Research Institute (IN)
- Guru Angad Dev Veterinary and Animal Sciences University (IN)
- Sam Higginbottom Institute of Agriculture (IN)
- Govind Ballabh Pant University of Agriculture and Technology (IN)
- Kerala Veterinary and Animal Sciences University (IN)
- Banaras Hindu University (IN)
Publication Details
- Journal
- Annals of Medicine and Surgery
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1097/ms9.0000000000003230
- Citations
- 2
- Primary Topic
- Phytochemicals and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 4.76