Impact of Antithrombotic Therapy on Survival Outcomes in Advanced Melanoma Patients Receiving Targeted Therapy: Insights from the Prospective Multicenter ADOReg Registry
Background: BRAF/MEK inhibitors (BRAFi/MEKi) improve clinical outcomes in patients with BRAF-mutated metastatic melanoma.However, the treatment is associated with a risk of cardiotoxicity, potentially leading to decline in left ventricular ejection fraction (LVEF).This study aimed to evaluate the incidence, timeline, risk
Authors
- Patrick Terheyden (ORCID: https://orcid.org/0000-0002-5894-1677)
- Carola Berking
- Jochen Sven Utikal (ORCID: https://orcid.org/0000-0001-5316-0241)
- Darren J. Smit (ORCID: https://orcid.org/0000-0002-3288-3659)
- Rudolf Alexander Herbst (ORCID: https://orcid.org/0000-0002-4238-9486)
- Christoffer Gebhardt (ORCID: https://orcid.org/0000-0001-7090-9584)
- Traci Zell
- Michael Weichenthal (ORCID: https://orcid.org/0000-0002-9060-4961)
- Claudia Pföhler (ORCID: https://orcid.org/0000-0003-0384-114X)
- Sebastian Haferkamp (ORCID: https://orcid.org/0000-0002-3894-8345)
- Julian Kött (ORCID: https://orcid.org/0000-0003-2073-3909)
- Dirk Schadendorf (ORCID: https://orcid.org/0000-0003-3524-7858)
- Friedegund Meier (ORCID: https://orcid.org/0000-0003-4340-9706)
- Glenn Geidel (ORCID: https://orcid.org/0009-0008-3999-5902)
- Fabian Ziller (ORCID: https://orcid.org/0000-0002-2519-1312)
- Benjamin Deitert (ORCID: https://orcid.org/0000-0003-2794-0003)
- Peter J. Mohr (ORCID: https://orcid.org/0000-0001-5068-3557)
- Sarah N. Belz
- Selma Ugurel (ORCID: https://orcid.org/0000-0002-9384-6704)
- Alexander T. Bauer (ORCID: https://orcid.org/0000-0003-3426-0073)
- Alessandra Rünger (ORCID: https://orcid.org/0000-0002-4465-5282)
- R. Gutzmer
- Nick Zimmermann (ORCID: https://orcid.org/0000-0003-2277-8000)
- Chiara L. Blomen (ORCID: https://orcid.org/0000-0002-9685-5390)
- Ulrike Leiter (ORCID: https://orcid.org/0000-0002-8019-1577)
- Stefan W. Schneider (ORCID: https://orcid.org/0000-0002-4679-7137)
- I. Heidrich
- Martin Kaatz (ORCID: https://orcid.org/0000-0002-0650-2576)
- Imke von Wasielewski
- Atefeh Abedini (ORCID: https://orcid.org/0000-0002-3821-7016)
- Jens Ulrich
Institutions
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Medical Center Freiburg (DE)
- Dorothea Dix Hospital (US)
- University Hospital Heidelberg (DE)
- University Hospital Regensburg (DE)
- Medizinische Hochschule Hannover (DE)
- Universitätsklinikum Erlangen (DE)
- SRH Wald-Klinikum Gera (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Schleswig-Holstein (DE)
- Essen University Hospital (DE)
- University Cancer Center Hamburg (DE)
- Elbe Kliniken Stade-Buxtehude (DE)
- Helios Klinikum Erfurt (DE)
- Comprehensive Cancer Center Erlangen (DE)
- University Medical Centre Mannheim (DE)
- University Hospital Carl Gustav Carus (DE)
- Klinikum Chemnitz (DE)
- Johannes Wesling Klinikum Minden (DE)
- University of Duisburg-Essen (DE)
- University of Tübingen (DE)
- Saarland University (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- EJC Skin Cancer
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.ejcskn.2025.100619
- Primary Topic
- Cutaneous Melanoma Detection and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00