Development and Validation of Imaging‐Free Myocardial Fibrosis Prediction Models, Association with Outcomes, and Sample Size Estimation for Phase 3 Trials
Predicted ECV (derived without tomographic imaging) associates with outcomes and efficiently identifies vulnerable patients who might benefit from treatment. Predicted ECV may foster the design of phase 3 trials targeting myocardial fibrosis with higher numbers of screened and enrolled participants, but with simplified eligibility criteria, avoiding the complexity of tomographic imaging.
Authors
- Nicholas Black (ORCID: https://orcid.org/0000-0002-0089-6180)
- Joshua Bradley (ORCID: https://orcid.org/0000-0002-0958-7392)
- Mark C. Petrie (ORCID: https://orcid.org/0000-0002-6333-9496)
- Gavin A. Lewis (ORCID: https://orcid.org/0000-0001-6754-836X)
- Javed Butler (ORCID: https://orcid.org/0000-0001-7683-4720)
- Christopher Orsborne (ORCID: https://orcid.org/0000-0002-9514-110X)
- Theresa A. McDonagh (ORCID: https://orcid.org/0000-0003-1305-9602)
- Chris Miller (ORCID: https://orcid.org/0000-0002-5957-7088)
- Martin Ugander (ORCID: https://orcid.org/0000-0003-3665-2038)
- João L. Cavalcante (ORCID: https://orcid.org/0000-0002-3632-2074)
- J. Farrant (ORCID: https://orcid.org/0000-0002-9241-2410)
- Jakub Lagan (ORCID: https://orcid.org/0000-0003-0017-9082)
- Matthias Schmitt (ORCID: https://orcid.org/0000-0001-8514-0261)
- Fardad Soltani (ORCID: https://orcid.org/0000-0003-2030-9761)
- Erik B. Schelbert (ORCID: https://orcid.org/0000-0003-0356-4437)
Institutions
- Abbott Northwestern Hospital (US)
- Karolinska University Hospital (SE)
- University of Liverpool (GB)
- United Hospital (US)
- Royal North Shore Hospital (AU)
- Royal Liverpool University Hospital (GB)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University of Mississippi (US)
- Manchester University NHS Foundation Trust (GB)
- Baylor Medical Center at Garland (US)
- Minneapolis Heart Institute Foundation (US)
- King's College Hospital (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1161/jaha.124.037254
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00