Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism
Exogenous GABA alleviated TS-like behavior in rats by reducing harmful gut flora and modulating striatal GABA-glutamate metabolism. Despite challenges like low blood-brain barrier permeability and dose safety in humans, GABA's therapeutic potential may be realized through prodrug development and optimized dosing. These findings are preliminary and require further clinical validation.
Authors
- Xiaoyu Tian (ORCID: https://orcid.org/0000-0003-2996-5212)
- Haishui Shi (ORCID: https://orcid.org/0000-0002-7478-4405)
- Ying Xu (ORCID: https://orcid.org/0000-0002-6689-7768)
- Hao Feng (ORCID: https://orcid.org/0000-0003-4066-8104)
- Lina Li (ORCID: https://orcid.org/0000-0003-3481-4574)
- Shuang Wang (ORCID: https://orcid.org/0000-0002-8261-0018)
- Xijing He (ORCID: https://orcid.org/0000-0002-0465-5376)
- Huifeng Zhang (ORCID: https://orcid.org/0000-0002-9818-7904)
- Li Song (ORCID: https://orcid.org/0000-0002-3681-5514)
- Xincheng Li (ORCID: https://orcid.org/0009-0006-4675-0773)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
- Hebei GEO University (CN)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ndt.s512191
- Citations
- 3
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 6.92