Entry Efficiency, Protease Dependence, and Antibody-Mediated Neutralization of SARS-CoV-2 Sublineages KP.3.1.1 and XEC
Our findings demonstrate that JN.1, KP.3.1.1, and XEC, like their predecessor BA.2.86, rely on TMPRSS2 for lung cell entry and remain sensitive to certain neutralizing monoclonal antibodies. However, these variants differ in their ability to utilize ACE2 species orthologs for cell entry.
Authors
- Stefan Pöhlmann (ORCID: https://orcid.org/0000-0001-6086-9136)
- Inga Nehlmeier (ORCID: https://orcid.org/0000-0002-8752-7491)
- Markus Hoffmann (ORCID: https://orcid.org/0000-0003-4603-7696)
- Amy Kempf
- Sebastian Schulz (ORCID: https://orcid.org/0000-0001-6554-3346)
- Hans‐Martin Jäck (ORCID: https://orcid.org/0000-0002-6332-8463)
- Prerna Arora (ORCID: https://orcid.org/0000-0002-0618-8652)
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- German Primate Center (DE)
- University of Göttingen (DE)
Publication Details
- Journal
- Vaccines
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3390/vaccines13040385
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 4.19
Funders
- Bayerische Forschungsstiftung