Acute effects of 50 mg additive oral sildenafil on invasive exercise haemodynamics in pulmonary vascular disease
Patients with PVD, showed favourable acute pulmonary haemodynamic changes during exercise after additive sildenafil, indicated by a reduced mPAP and mPAP/CO slope. Sildenafil was generally well tolerated despite lower blood pressure. Further investigation is needed to determine if sildenafil as a "pill-in-the-pocket" strategy improves exercise capacity in PVD patients.
Authors
- Meret Bauer
- Silvia Ulrich (ORCID: https://orcid.org/0000-0002-5250-5022)
- Julian Müller (ORCID: https://orcid.org/0000-0003-4059-5937)
- Mona Lichtblau (ORCID: https://orcid.org/0000-0003-4485-1758)
- Esther Irene Schwarz (ORCID: https://orcid.org/0000-0001-8840-981X)
- Stéphanie Saxer (ORCID: https://orcid.org/0000-0002-3278-6277)
- Laura C. Mayer (ORCID: https://orcid.org/0009-0004-4949-8548)
- Michaël Furian (ORCID: https://orcid.org/0000-0002-8518-5029)
- Simon Schneider (ORCID: https://orcid.org/0000-0003-3635-0515)
Institutions
- Major League Baseball (US)
- University Hospital of Zurich (CH)
- OST - Ostschweizer Fachhochschule (CH)
- University of Applied Sciences St. Gallen (CH)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1183/23120541.01392-2024
- Citations
- 1
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung