Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze
Nonatopic wheeze is associated with a depletion of <i>Bacteroides</i> in infancy, and in children not exclusively breastfed the risk is further increased among those with high endogenous SIgA levels. These results highlight the importance of the interplay between the gut microbiota and immune system development during critical periods in early life and how it is linked to nonatopic wheeze in childhood.
Authors
- Theo J. Moraes (ORCID: https://orcid.org/0000-0001-9968-6601)
- Piush J. Mandhane (ORCID: https://orcid.org/0000-0003-3682-9120)
- Matthew Hicks (ORCID: https://orcid.org/0000-0002-5534-763X)
- Stuart E. Turvey (ORCID: https://orcid.org/0000-0003-1599-1065)
- Padmaja Subbarao (ORCID: https://orcid.org/0000-0003-0394-1933)
- Anne Hicks (ORCID: https://orcid.org/0000-0001-6553-3826)
- Hein M. Tun (ORCID: https://orcid.org/0000-0001-7597-5062)
- Anita Luba Kozyrskyj (ORCID: https://orcid.org/0000-0002-2869-9242)
- Linn E. Moore (ORCID: https://orcid.org/0000-0003-0451-460X)
- Catherine J. Field (ORCID: https://orcid.org/0000-0001-7285-4767)
- Elinor Simons
Institutions
- University of British Columbia (CA)
- University of Alberta (CA)
- Chinese University of Hong Kong (HK)
- University of Toronto (CA)
- Hospital for Sick Children (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- Hong Kong Jockey Club (HK)
- Public Health Ontario (CA)
- SickKids Foundation (CA)
- BC Children's Hospital (CA)
- Child and Family Research Institute (CA)
- University of Manitoba (CA)
- UCSI University (MY)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1183/23120541.00240-2025
- Citations
- 1
- Primary Topic
- Pediatric health and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.52