Severe tremors induced by tiletamine e-cigarette and alcohol use: a case report
Polydrug users, particularly those using NMDAR antagonists and gamma-aminobutyric acid type A receptor (GABA-AR) agonists, may be at increased risk of developing tiletamine dependence, with more severe consequences due to cross-addiction. The combination of alcohol and tiletamine could exacerbate neuroexcitotoxicity during withdrawal, potentially contributing to severe tremors. The successful management of tremors with a combination of neuroinhibitory therapies suggested an effective strategy for complex cases. Further studies are needed to better understand the long-term impacts and risks of tiletamine dependence.
Authors
- Xuhui Zhou (ORCID: https://orcid.org/0000-0002-2038-9901)
- Shuai Yang (ORCID: https://orcid.org/0000-0002-3993-4308)
- Xiaolei Zhou (ORCID: https://orcid.org/0000-0002-7992-637X)
- Ewen Tu (ORCID: https://orcid.org/0000-0003-3598-5455)
- Qian Chen (ORCID: https://orcid.org/0000-0002-2411-2838)
- Shi Li (ORCID: https://orcid.org/0009-0009-5285-4044)
- Bo Zhou (ORCID: https://orcid.org/0000-0002-5985-8998)
- Haifeng Zhang (ORCID: https://orcid.org/0000-0003-1938-3796)
Institutions
- Hunan University of Traditional Chinese Medicine (CN)
- Second People Hospital of Hunan (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
- Dongguan People’s Hospital (CN)
- Hunan Institute of Mental Health (CN)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-04-03
- DOI
- https://doi.org/10.3389/fpsyt.2025.1537822
- Citations
- 4
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 3.22