Y-90 Treatment Dose Delivery Uncertainty from Measurement Uncertainties

The objective of this note was to study the measurement uncertainties at each step of Yttrium-90 radioembolization. We studied the measurement uncertainty contribution from the dose calibrator accuracy during the initial dose assay, the survey meter accuracy, and the operator's reading uncertainties during the dose rate measurements. The propagation of these uncertainties was calculated to determine the final dose delivery uncertainty for various prescribed doses. The percentage of final dose delivered could be affected significantly by the uncertainties associated with operation at each step of dose assay and dose rate measurements, especially for low prescribed doses.