Display selection of peptide ligands for helical aromatic foldamers
Helical aromatic oligoamide foldamers with a cluster of five biogenic side chains at their surface were designed and synthesized. Display selection of thioether macrocyclic peptides against these targets generated low micromolar binders that are highly selective for the side-chain arrangement.
Authors
- Ryan T. Howard (ORCID: https://orcid.org/0000-0002-9340-8536)
- Hiroaki Suga (ORCID: https://orcid.org/0000-0002-5298-9186)
- Simon J. Dawson
- Céline Douat (ORCID: https://orcid.org/0000-0003-2678-1047)
- Ivan Huc (ORCID: https://orcid.org/0000-0001-7036-9696)
- Joseph M. Rogers (ORCID: https://orcid.org/0000-0002-1313-4089)
- Sunbum Kwon (ORCID: https://orcid.org/0000-0003-0027-6990)
- Line M. Langhorn (ORCID: https://orcid.org/0000-0003-1696-0789)
- Lingfei Wang (ORCID: https://orcid.org/0000-0003-1675-0941)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Institut Européen de Chimie et Biologie (FR)
- Institut Polytechnique de Bordeaux (FR)
- The University of Tokyo (JP)
- Ludwig-Maximilians-Universität München (DE)
- Chuo University (JP)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00228a
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Japan Society for the Promotion of Science