Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice
Taken together, we demonstrate that life-long and repeated transfer of microbiota material from young mice improved age-related processes including coordinative ability (rotarod), intestinal permeability, and both metabolic and inflammatory profiles mainly of macrophages but also of other immune cells. Video Abstract.
Authors
- Antonella Fazio (ORCID: https://orcid.org/0009-0003-0309-7303)
- Joana P. Bernardes
- Jacob Hamm (ORCID: https://orcid.org/0000-0003-4960-6858)
- Nina Sommer
- Maren Falk‐Paulsen
- Go Ito (ORCID: https://orcid.org/0009-0004-7488-0335)
- Lena Best (ORCID: https://orcid.org/0000-0003-2772-153X)
- Γεώργιος Μαρίνος (ORCID: https://orcid.org/0000-0002-6443-7696)
- Felix Sommer (ORCID: https://orcid.org/0000-0002-6545-3487)
- Philip Rosenstiel (ORCID: https://orcid.org/0000-0002-9692-8828)
- A. Samer Kadibalban (ORCID: https://orcid.org/0009-0001-9726-543X)
- Berith Messner
- Christoph Kaleta
- Víctor A. López-Agudelo (ORCID: https://orcid.org/0000-0003-1339-972X)
Institutions
- Universität Hamburg (DE)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Institute for Health Economics and Policy (JP)
- University of Göttingen (DE)
Publication Details
- Journal
- Microbiome
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s40168-025-02089-8
- Citations
- 8
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 6.45
Funders
- Deutsche Forschungsgemeinschaft