Siltuximab for the treatment of early complications after chimeric antigen receptor T-cell therapy for acute lymphoblastic leukemia in children, adolescents, and young adults
To the best of our knowledge, we present the largest reported cohort of patients treated with siltuximab for CRS following CAR T-cell therapy for B-ALL. Siltuximab's safety profile and its inhibition of IL-6 effects suggest that it should be investigated as first-line therapy in prospective clinical trials.
Authors
- Carmen Mestre‐Durán (ORCID: https://orcid.org/0000-0003-3569-2345)
- José María Sánchez‐Pina (ORCID: https://orcid.org/0000-0002-9181-0900)
- Susana Rives (ORCID: https://orcid.org/0000-0002-5658-1831)
- Víctor Galán‐Gómez (ORCID: https://orcid.org/0000-0002-2682-9664)
- Berta González‐Martínez
- Pere Barba (ORCID: https://orcid.org/0000-0001-7076-7969)
- Antonio Pérez‐Martínez (ORCID: https://orcid.org/0000-0002-6436-9195)
- Mi Kwon (ORCID: https://orcid.org/0000-0002-3855-7774)
- María Sánchez‐Martín (ORCID: https://orcid.org/0000-0002-0425-9883)
- Isabel Mirones (ORCID: https://orcid.org/0000-0001-6921-4590)
- Blanca Herrero (ORCID: https://orcid.org/0000-0002-8083-5280)
- Anna Alonso‐Saladrigues (ORCID: https://orcid.org/0000-0002-3195-5470)
- Águeda Molinos-Quintana (ORCID: https://orcid.org/0000-0003-4972-917X)
- Gema Casado
- Jordi Minguillón (ORCID: https://orcid.org/0000-0003-2124-8294)
- Cristina Aguirre‐Portolés (ORCID: https://orcid.org/0000-0001-9074-8386)
- Isabel Martínez-Romera
- Pascual Balsalobre
- Odelaisy León‐Triana (ORCID: https://orcid.org/0000-0002-7509-7754)
- Carlos Echecopar (ORCID: https://orcid.org/0000-0002-3916-4091)
- Carlos González Pérez (ORCID: https://orcid.org/0000-0001-8667-2403)
Institutions
- Hebron University (PS)
- Universitat Autònoma de Barcelona (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Hospital Universitario La Paz (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Research Institute Hospital 12 de Octubre (ES)
- Hospital La Paz Institute for Health Research (ES)
- Hospital Infantil Universitario Niño Jesús (ES)
- Unidades Centrales Científico-Técnicas (ES)
- Sant Joan de Déu Research Foundation (ES)
- Spanish Society of Hematology and Hemotherapy (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital del Niño (PA)
- Universidad Autónoma de Madrid (ES)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s40164-025-00638-3
- Citations
- 4
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- European Commission
- CRIS Cancer Foundation
- Instituto de Salud Carlos III