Prediction for cardiac and pulmonary toxicity in a multicentric cohort of advanced stage NSCLC patients using sub-regions of the heart
The pulmonary dosimetric parameter MLD successfully predicted CAE grade ≥ 3 in a cohort treated with either photons or protons. Cardiac dosimetric parameters as well as spatial parameters did not perform similarly. No parameters were found to significantly predict RP in the investigated cohorts.
Authors
- Johan Bussink (ORCID: https://orcid.org/0000-0002-5751-4796)
- Steffen Löck (ORCID: https://orcid.org/0000-0002-7017-3738)
- René Monshouwer (ORCID: https://orcid.org/0000-0002-9611-3901)
- Albrecht Weiß (ORCID: https://orcid.org/0009-0003-1112-7277)
- Ting Xu (ORCID: https://orcid.org/0000-0002-7851-3389)
- Miguel Garrett Fernandes
- Zhongxing Liao (ORCID: https://orcid.org/0000-0002-2224-9478)
- Esther G.C. Troost (ORCID: https://orcid.org/0000-0001-9550-9050)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Radboud University Nijmegen (NL)
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital Heidelberg (DE)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- National Center for Tumor Diseases (DE)
- OncoRay (DE)
- University Hospital Carl Gustav Carus (DE)
- University College London (GB)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Clinical and Translational Radiation Oncology
- Published
- 2025-04-03
- DOI
- https://doi.org/10.1016/j.ctro.2025.100952
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00