Parental kynurenine 3-monooxygenase genotype in mice directs sex-specific behavioral outcomes in offspring
These findings suggest that Kmo deficiency impacts KP biochemistry, sleep behavior, and brain mitochondrial function. Even though WT-Kmo<sup>+/+</sup> inherit identical genetic material as WT-Control, their development might be shaped by the parent's physiology, behavior, or metabolic state influenced by their Kmo genotype, leading to phenotypic sex-specific differences in offspring.
Authors
- Ana Pocivavsek (ORCID: https://orcid.org/0000-0002-3817-3201)
- Sarah Beggiato (ORCID: https://orcid.org/0000-0002-8826-7556)
- Maria V. Piroli
- Norma Frizzell (ORCID: https://orcid.org/0000-0002-5080-4176)
- Gerardo G. Piroli
- Holland M. Smith
- Emma J Sandago
- Snezana Milosavljevic
Institutions
- University of South Carolina (US)
- University of Ferrara (IT)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s13293-025-00703-w
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- University of South Carolina
- National Institutes of Health