Bioinformatics analysis and experimental validation of potential targets and pathways in chronic kidney disease associated with renal fibrosis
Our findings provide compelling evidence that miR-223-3p acts as a suppressor of EMT in CKD by specifically targeting the CHUK and modulating the PI3K/Akt pathway, which holds great promise as a novel therapeutic target for CKD treatment. Additionally, this study offers a potential avenue for the development of future interventions aimed at halting or reversing the progression of CKD.
Authors
- Na Li (ORCID: https://orcid.org/0000-0002-6227-8433)
- Peng Wang (ORCID: https://orcid.org/0000-0002-2337-5812)
- Jianjun Yang (ORCID: https://orcid.org/0000-0002-8332-5526)
- Wei Gong
- Cui Huimin
- Lin Hong
- Zhao Yuxin
Institutions
- Ningxia Medical University (CN)
- Ningxia Medical University General Hospital (CN)
- Ningxia Center for Diseases Prevention and Control (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s12967-024-06058-x
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Science and Technology Department of Ningxia
- National Natural Science Foundation of China
- Natural Science Foundation of Ningxia Province