Rutin ameliorates stress–induced blood‒brain barrier dysfunction and cognitive decline via the endothelial HDAC1‒Claudin–5 axis
This work establishes a protective role of rutin in regulating BMEC function and BBB integrity, and reveals that rutin is a potential drug candidate for curing chronic stress-induced cognitive deficits.
Authors
- Yun Fu Zhao (ORCID: https://orcid.org/0000-0002-6357-9422)
- Feng Hong (ORCID: https://orcid.org/0000-0002-2053-9199)
- Xue Wang (ORCID: https://orcid.org/0009-0009-3062-2103)
- Ling Zhang (ORCID: https://orcid.org/0000-0001-6375-3067)
- Jinshan Li (ORCID: https://orcid.org/0000-0002-6894-9760)
- Zhao-Xin Sun
- Min Zhou (ORCID: https://orcid.org/0000-0003-1838-9010)
- Fang Xie (ORCID: https://orcid.org/0000-0003-2528-5041)
- Zhaowei Sun (ORCID: https://orcid.org/0000-0002-3195-0186)
- Lingjia Qian
Institutions
- Beijing Institute of Education (CN)
- Tianjin University of Sport (CN)
- Capital Medical University (CN)
- Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s12987-025-00639-8
- Citations
- 12
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 10.11
Funders
- National Natural Science Foundation of China