Heme-induced lung injury in human precision cut lung slices: a new model for acute lung injury
Heme induced inflammatory cytokine release and cell death in human PCLS, resembling the patterns observed in blood samples from patients with COVID-19 and ARDS. Thus, heme-stimulated PCLS represent a novel ex vivo model for mechanistic studies for acute lung injury and ARDS.
Authors
- Savvina Chortarea (ORCID: https://orcid.org/0000-0003-1517-3628)
- Carlos Machahua (ORCID: https://orcid.org/0000-0003-4964-7393)
- Kleanthis Fytianos (ORCID: https://orcid.org/0000-0002-7082-9493)
- Manuela Funke-Chambour (ORCID: https://orcid.org/0000-0003-3417-5872)
- Patrick Dorn (ORCID: https://orcid.org/0000-0002-7203-3122)
- Thomas M. Marti (ORCID: https://orcid.org/0000-0003-3005-220X)
- Namrata Kewalramani (ORCID: https://orcid.org/0000-0002-8305-1502)
- Christophe von Garnier (ORCID: https://orcid.org/0000-0003-3585-9176)
- Cas Zandbergen
- Jessica Beretta-Piccoli
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- CSL (Switzerland) (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-04-02
- DOI
- https://doi.org/10.1186/s12931-025-03191-z
- Citations
- 2
- Primary Topic
- Heme Oxygenase-1 and Carbon Monoxide
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- CSL Behring
- University of Bern